Anti-PSMF1 monoclonal antibody, clone 3E8

Antibody Isotype

IgG1

Clone

3E8

Species Reactivity

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-271 of Human Proteasome Inhibitor subunit 1 PI3 1 (NP_848693) produced in HEK293T cells.

Conjugate

Application Notes

WB: 1/200 - 1/2000; ICC/IF: 1/100;

Alternative Names

PSMF1; proteasome (prosome, macropain) inhibitor subunit 1 (PI31); proteasome inhibitor PI31 subunit; PI31; proteasome inhibitor hP131 subunit; hPI31;

Entrez Gene ID

UniProt ID

Antigen Description

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem.