Anti-PSMD11 monoclonal antibody, clone BU2G5

Antibody Isotype

IgG1

Clone

BU2G5

Species Reactivity

Human; Mouse

Immunogen

Recombinant protein corresponding to full length human PSMD11.

Conjugate

Alternative Names

PSMD11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; 26S proteasome non-ATPase regulatory subunit 11; MGC3844; p44.5; Rpn6; S9; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit RP

Entrez Gene ID

UniProt ID

Antigen Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kapp