Anti-PSMC2 monoclonal antibody (CAB-4336MH)

Mouse anti-PSMC2 monoclonal antibody for ELISA, WB, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5D20-3D9
Species Reactivity
Human
Immunogen
PSMC2 (AAH02589, 1 a.a.~434 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PSMC2; proteasome (prosome, macropain) 26S subunit, ATPase, 2; 26S protease regulatory subunit 7; mammalian suppressor of sgv 1 of yeast; MSS1; Nbla10058
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PSMC2 (Proteasome 26S Subunit, ATPase 2) is a Protein Coding gene. Diseases associated with PSMC2 include hiv-1. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and ATPase activity. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Pathway
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kapp.

Citations


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References


Tan, YL; Peng, X; et al. Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. JOURNAL OF BURN CARE & RESEARCH 27:226-233(2006).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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