Anti-PSMB4 (aa 233-243) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: C-QIATVTEKGVE, corresponding to internal sequence amino acids 233-243 of Human Proteasome subunit beta type 4 (NP_002787.2).

Conjugate

Application Notes

WB: 0.3 - 1 μg/ml; IHC-P: 3.75 μg/ml;

Alternative Names

PSMB4; proteasome (prosome, macropain) subunit, beta type, 4; HN3; HsN3; PROS26; PROS-26; proteasome subunit beta type-4; hsBPROS26; proteasome chain 3; macropain beta chain; proteasome beta chain; 26 kDa prosomal protein; proteasome subunit HsN3; proteas

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome (By similarity). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Pathway

APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of mitotic proteins; AUF1 (hnRNP D0) destabilizes mRNA; Activation of NF-kappaB in B cells