Anti-PRKCG monoclonal antibody, clone N220

Antibody Isotype

IgG1

Clone

N220

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein corresponding to amino acids 499-697 of human PRKCG.

Conjugate

Application Notes

ELISA (1:2000); Immunocytochemistry (1:100); Immunoprecipitation (1-5 μl); WB (1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

PRKCG; protein kinase C, gamma; PKCG, SCA14; protein kinase C gamma type; MGC57564; PKC gamma; PKCC; PKCG; SCA14; PKC-gamma;

Entrez Gene ID

UniProt ID

Antigen Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

Pathway

African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Amphetamine addiction, organism-specific biosystem;