Anti-PRKCE (aa 301-400) polyclonal antibody

Species Reactivity

Human; Mouse

Immunogen

PRKCE (NP_005391, 301 a.a. ~ 400 a.a) partial recombinant protein with GST tag. The sequence is KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQA

Conjugate

Alternative Names

PRKCE; protein kinase C, epsilon; PKCE; nPKC-epsilon; protein kinase C epsilon type;

Entrez Gene ID

UniProt ID

Antigen Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

Pathway

B Cell Receptor Signaling Pathway; Calcium Regulation in the Cardiac Cell; DAP12 interactions; Disease