Anti-PRKAA1 monoclonal antibody, clone 3C8

Antibody Isotype

IgG1

Clone

3C8

Species Reactivity

Mouse; Rat; Human; Monkey

Immunogen

Purified recombinant fragment of Human AMPK alpha 1 expressed in E. Coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; ICC/IF: 1/200 - 1/1000; ELISA: 1/10000; IHC-P: 1/200 - 1/1000; Flow Cyt: 1/200 - 1/1000;

Alternative Names

PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; 5-AMP-activated protein kinase catalytic subunit alpha-1; AMPK; alpha; 1; AMPKa1; AMPK alpha 1; AMPK subunit alpha-1; tau-protein kinase PRKAA1; AMP -activate kinase alpha 1 subunit; AMP-ac

Entrez Gene ID

UniProt ID

Antigen Description

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Pathway

AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy Metabolism, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem;