Anti-PRCC monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PRCC is used for rabbit immunization.

Conjugate

Alternative Names

PRCC; papillary renal cell carcinoma (translocation-associated); proline-rich protein PRCC; RCCP1; papillary renal cell carcinoma translocation-associated gene protein; TPRC; MGC4723; MGC17178;

Entrez Gene ID

UniProt ID

Antigen Description

In a subset of papillary renal cell carcinomas, a t(X; 1)(p11; q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to this gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Pathway

Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;