Anti-PPP2R2D monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PPP2R2D is used for rabbit immunization.

Conjugate

Alternative Names

PPP2R2D; protein phosphatase 2, regulatory subunit B, delta; MDS026; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform B55-delta; PP2A s

Entrez Gene ID

UniProt ID

Antigen Description

PPP2R2D (protein phosphatase 2, regulatory subunit B, delta) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PPP2R2D include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Mitotic M-M/G1 phases and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2B. B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Pathway

Adrenergic signaling in cardiomyocytes; Cell Cycle; Cell Cycle, Mitotic; Chagas disease (American trypanosomiasis); Dopaminergic synapse; Hepatitis C; Hippo signaling pathway; Hippo signaling pathway; M Phase; MASTL Facilitates Mitotic Progression; Mitotic Prophase;