Specifications
Immunogen
Recombinant protein corresponding to C-terminus of human PPP2CB.
Applications
Application Notes
ELISA (1:5000-1:20000); WB (1:100-1:2000) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2Abeta; protein phosphatase 2A catalytic subuni
Product Background
Antigen Description
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.
Pathway
Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Beta-catenin phosphorylation cascade, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Prowatke, I; Devens, F; et al. Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. BRITISH JOURNAL OF CANCER 96:82-88(2007).
JONES, TA; BARKER, HM; et al. LOCALIZATION OF THE GENES ENCODING THE CATALYTIC SUBUNITS OF PROTEIN PHOSPHATASE-2A TO HUMAN-CHROMOSOME BANDS 5Q23 -]Q31 AND 8P12 -]P11.2, RESPECTIVELY. CYTOGENETICS AND CELL GENETICS 63:35-&(1993).