Anti-PPP1R9B (aa 800-817) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Rat

Immunogen

Synthetic peptide: KISELEGNLQTLRNSNST conjugated to KLH, corresponding to C terminal amino acids 800-817 of Rat Neurabin 2

Conjugate

Application Notes

ICC/IF: Use at a concentration of 10 - 20 μg/ml. IP: Use 10-20 μg. WB: Use at a concentration of 1 - 2 μg/ml. Predicted molecular weight: 89 kDa. Array: Use at an assay dependent dilution.

Alternative Names

PPP1R9B; protein phosphatase 1, regulatory subunit 9B; Neb2; neurabin-2; p130; PP1bp134; neurabin 2; nuerabin 2; neurabin-II; spinophilin; neural tissue-specific F-actin-binding protein II;

Entrez Gene ID

UniProt ID

Antigen Description

Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.