Anti-PPME1 monoclonal antibody (DCABH-662)

Mouse anti-Human PPME1 monoclonal antibody for WB, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
21C3
Species Reactivity
Human
Immunogen
Recombinant full length Human PPME1 produced in HEK293T cells (NP_057231).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PPME1; protein phosphatase methylesterase 1; PME 1; protein phosphatase methylesterase-1; PME-1; FLJ22226
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. Diseases associated with PPME1 include malignant glioma. GO annotations related to this gene include protein phosphatase binding and protein phosphatase inhibitor activity. This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
Antigen Description
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro). Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. The function about PPME1 antigen include carboxylesterase activity; hydrolase activity; protein C-terminal methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity.

Citations


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References


Longin, S; Zwaenepoel, K; et al. Spatial control of protein phosphatase 2A (de)methylation. EXPERIMENTAL CELL RESEARCH 314:68-81(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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