Anti-PPBP polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human CXCL7/NAP-2 . Ala59-Asp128 Accession Number P02775

Conjugate

Biotin

Application Notes

Western Blot: 0.1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4086 - DPABY-514

Alternative Names

PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III; platelet basic protein; thrombocidin 1; thrombocidin 2; beta-t

Entrez Gene ID

5473

UniProt ID

P02775

Antigen Description

Neutrophil activating peptide 2 (NAP-2), connective tissue activating protein III (CTAP-III) and beta-thrombogulin (beta-TG), are proteolytically processed carboxy-terminal fragments of platelet basic protein (PBP), which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines and is named CXCL7. Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, NAP-2 binds CXCR2 and chemoattracts and activates neutrophils.

Pathway

Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Hemostasis;