PPAPDC1B (phosphatidic acid phosphatase type 2 domain containing 1B) is a protein-coding gene. Diseases associated with PPAPDC1B include hepatocellular carcinoma, and breast cancer, and among its related super-pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include phosphatidate phosphatase activity. An important paralog of this gene is PPAPDC1A. Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
Pathway
Fcgamma receptor (FCGR) dependent phagocytosis; Immune System; Innate Immune System; Role of phospholipids in phagocytosis.
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