Anti-POLR2G (aa 145-153) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human POLR2G aa 145-153 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P62487

Conjugate

Application Notes

WB: 1/100 - 1/500; Flow Cyt: 1/10 - 1/50.

Alternative Names

POLR2G; polymerase (RNA) II (DNA directed) polypeptide G; DNA-directed RNA polymerase II subunit RPB7; hRPB19; hsRPB7; RPB7; RNA polymerase II subunit B7; RNA polymerase II 19 kDa subunit; RNA polymerase II seventh subunit; DNA-directed RNA polymerase II

Entrez Gene ID

UniProt ID

Antigen Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.

Pathway

Abortive elongation of HIV-1 transcript in the absence of Tat; DNA Repair; Disease; Dual incision reaction in TC-NER; Eukaryotic Transcription Initiation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of HIV-1 elongation complex in