Synthetic peptide within Human POLR2G aa 145-153 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P62487
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/100 - 1/500; Flow Cyt: 1/10 - 1/50.
Target
Alternative Names
POLR2G; polymerase (RNA) II (DNA directed) polypeptide G; DNA-directed RNA polymerase II subunit RPB7; hRPB19; hsRPB7; RPB7; RNA polymerase II subunit B7; RNA polymerase II 19 kDa subunit; RNA polymerase II seventh subunit; DNA-directed RNA polymerase II
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.
Pathway
Abortive elongation of HIV-1 transcript in the absence of Tat; DNA Repair; Disease; Dual incision reaction in TC-NER; Eukaryotic Transcription Initiation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of HIV-1 elongation complex in
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Blume, SW; Meng, Z; et al. The 5 '-untransiated RNA of the human dhfr minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter. JOURNAL OF CELLULAR BIOCHEMISTRY 88:165-180(2003).
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COA
Certificate of Analysis
