Anti-PLTP monoclonal antibody (CAB-4243MH)

Mouse anti-PLTP monoclonal antibody for ELISA, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3G4-H5
Species Reactivity
Human
Immunogen
PLTP (AAH05045, 1 a.a. - 422 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PLTP; phospholipid transfer protein; BPI fold containing family E; BPIFE; lipid transfer protein II; HDLCQ9
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PLTP (Phospholipid Transfer Protein) is a Protein Coding gene. Diseases associated with PLTP include hyperalphalipoproteinemia and neurologic diseases. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPI. The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability. Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene. The function about PLTP antigen include lipid binding.
Pathway
HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem; PPAR signaling pathway, conserved biosystem.

Citations


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References


Tuomainen, AM; Hyvarinen, K; et al. The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice. MICROBIAL PATHOGENESIS 51:217-224(2011).
Cheung, MC; Wolfbauer, G; et al. Plasma phospholipid mass transfer rate: Relationship to plasma phospholipid and cholesteryl ester transfer activities and lipid parameters. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1303:103-110(1996).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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