Anti-PLIN5 polyclonal antibody (DPAB-DC2954)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to amino acids 400-463 of mouse Plin5.
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.5-2 μg/mL. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PLIN5; perilipin 5; MLDP; Lsdp5; PAT-1; AI415325
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PLIN5 (Perilipin 5) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and lipase binding. An important paralog of this gene is PLIN2. Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al. , 2007 [PubMed 17234449]).
Antigen Description
PLIN5 (perilipin 5) is a protein-coding gene. Diseases associated with PLIN5 include obesity. An important paralog of this gene is PLIN2. Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). The function about PLIN5 antigen include identical protein binding; lipase binding; protein binding.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Heid, H; Rickelt, S; et al. Lipid Droplets, Perilipins and Cytokeratins - Unravelled Liaisons in Epithelium-Derived Cells. PLOS ONE 8:-(2013).
McDonough, PM; Maciejewski-Lenoir, D; et al. Differential Phosphorylation of Perilipin 1A at the Initiation of Lipolysis Revealed by Novel Monoclonal Antibodies and High Content Analysis. PLOS ONE 8:-(2013).

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