Anti-PLCG1 monoclonal antibody, clone FQ3633Z Knockout Validated

Antibody Isotype

IgG

Clone

FQ3633Z

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues near the C terminus of human Phospholipase C gamma 1.

Conjugate

Alternative Names

PLCG1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148) , PLC1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; NCKAP3; PLC II; PLC148; PLCgamma1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; p

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Pathway

Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem;