PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinas
PKN1, or HRI, mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at Ser-48 and Ser-51. It is synthesized in an inactive form that binds to the N-terminal domain of CDC37. It has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosporylation.
Pathway
G13 Signaling Pathway; Regulation of Androgen receptor activity; RhoA signaling pathway; Salmonella infection; Signaling mediated by p38-gamma and p38-delta; TNF-alpha/NF-kB Signaling Pathway;
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