Anti-PJA1 (aa 81-180) polyclonal antibody

Species Reactivity

Human

Immunogen

PJA1 (NP_660095, 81 a.a. ~ 180 a.a) partial recombinant protein with GST tag. The sequence is DSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVR GKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERD

Conjugate

Alternative Names

PJA1; praja ring finger 1, E3 ubiquitin protein ligase; RNF70; PRAJA1; E3 ubiquitin-protein ligase Praja-1; praja 1; RING finger protein 70;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants.

Pathway

Adaptive Immune System; Proteasome degradation; presentation;