Anti-PIWIL1 (aa 562-574) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: C-SNRKDKYDAIKKY, corresponding to internal sequence amino acids 562-574 of Human PIWIL1 (NP_004755.2; NP_001177900.1).

Conjugate

Application Notes

WB: 0.1μg/ml; IHC-P: 4 - 6 μg/ml.

Alternative Names

PIWIL1; piwi-like 1 (Drosophila); piwi (Drosophila) like 1; piwi-like protein 1; HIWI; PIWI; piwi homolog; MIWI;

Entrez Gene ID

UniProt ID

Antigen Description

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.

Pathway

Dorso-ventral axis formation;