Anti-PITX3 polyclonal antibody (DPABH-24500)

Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide: PEHGCKGQEHSD, corresponding to internal sequence amino acids 29-40 of Human PITX3 (NP_005020.1).
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.3 - 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PITX3; paired-like homeodomain 3; paired like homeodomain transcription factor 3; pituitary homeobox 3; homeobox protein PITX3; PTX3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PITX3 (Paired Like Homeodomain 3) is a Protein Coding gene. Diseases associated with PITX3 include anterior segment mesenchymal dysgenesis and cataract 11, multiple types. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PITX1. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
Antigen Description
Anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]: A range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Different mature anterior segment anomalies may exist alone or in combination, and are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum of anterior segment anomalies include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. Note=The disease is caused by mutations affecting the gene represented in this entry. Cataract 11, multiple types (CTRCT11) [MIM:610623]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT11 includes posterior polar cataract, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens. Some CTRCT11 patients can present a severe phenotype including microphthalmia and neurological dysfunction. Pituitary homeobox 3 is a protein that in humans is encoded by the PITX3 gene. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. The function about PITX3 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.

Citations


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References


Yang, DH; Peng, CG; et al. Pitx3-Transfected Astrocytes Secrete Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor and Protect Dopamine Neurons in Mesencephalon Cultures. JOURNAL OF NEUROSCIENCE RESEARCH 86:3393-3400(2008).
Hedlund, E; Pruszak, J; et al. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. STEM CELLS 26:1526-1536(2008).

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