Synthetic peptide within Human PIF1 aa 9-28. The exact sequence is proprietary. (NP_079325).Sequence: AGEYEDSELRCRVAVEELSP Database link: Q9H611
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/2000;
Target
Alternative Names
PIF1; PIF1 5-to-3 DNA helicase; PIF; C15orf20; ATP-dependent DNA helicase PIF1; petite integration frequency 1; PIF1 5-to-3 DNA helicase homolog; PIF1/RRM3 DNA helicase-like protein; DNA repair and recombination helicase PIF1;
DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA and telomeric DNA in a 5 to 3 polarity. Negatively regulates telomere length and such inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase (from SwissProt). Thought to be involved in evading DNA damage lesions and promoting stability of the replication fork.
Citations
Publication ()
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