Anti-PHLDA2 monoclonal antibody (CAB-4194MH)

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
6F5
Species Reactivity
Human
Immunogen
PHLDA2 (NP_003302, 1 a.a.~111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PHLDA2; pleckstrin homology-like domain, family A, member 2; TSSC3, tumor suppressing subtransferable candidate 3; pleckstrin homology-like domain family A member 2; BWR1C; HLDA2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PHLDA2 (Pleckstrin Homology Like Domain Family A Member 2) is a Protein Coding gene. Diseases associated with PHLDA2 include beckwith-wiedemann syndrome and hydatidiform mole, recurrent, 1. An important paralog of this gene is PHLDA1. This gene is located in a cluster of imprinted genes on chromosome 11p15. 5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
Antigen Description
This gene is one of several genes in the imprinted gene domain of 11p15. 5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth. Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.

Citations


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