Anti-PGF polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse PlGF-2 . Ala24-Pro158 Accession Number Q544A5

Conjugate

Application Notes

Western Blot: 0.1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4126 - DPABY-508

Alternative Names

PGF; placental growth factor; PIGF; Plgf; AI854365; placenta growth factor;

Entrez Gene ID

UniProt ID

Antigen Description

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra-and inter-chain disulfides are conserved among these growth factors. As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF-1, PlGF-2 and PlGF-3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. In normal mouse tissues, only one mouse PlGF mRNA encoding the equivalent of human PlGF-2 has been identified. Mouse PlGF-2 encodes a 158 amino acid residue precursor protein. Mouse PlGF-2 shares 65% amino acid identity with human PlGF-2. The gene for PlGF has been mapped to mouse chromosome 12 and human chromosome 14.

Pathway

Focal Adhesion; Focal adhesion; PI3K-Akt signaling pathway; Pathways in cancer; Rap1 signaling pathway; Ras signaling pathway; Signal Transduction; Signaling by VEGF;