Specifications
Species Reactivity
Rat; Dog; Human; Monkey
Immunogen
Recombinant full length Human Profilin 1 produced in HEK293T cells (NP_005013).
Applications
Application Notes
WB: 1/1000 - 1/2000; IHC-P: 1/50; Flow Cyt: 1/100; ICC/IF: 1/100;
Target
Alternative Names
PFN1; profilin 1; profilin-1; profilin I;
Product Background
Antigen Description
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Pathway
Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem;
Citations
Publication ()
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COA
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