Anti-PEMT polyclonal antibody (DPABT-H80655)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Conjugate
Unconjugated

Target


Alternative Names
PNMT; PEAMT; PEMPT; PEMT2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PEMT (Phosphatidylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PEMT include choline deficiency disease and whiplash. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include N-methyltransferase activity and phosphatidylethanolamine N-methyltransferase activity. Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Antigen Description
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT) is a transferase enzyme (EC 2. 1. 17) which converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. In humans it is encoded by the PEMT gene within the Smith-Magenis syndrome region on chromosome 17. The PEMT enzyme converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) via three sequential methylations by S-adenosyl methionine (SAM). The enzyme is found in endoplasmic reticulum and mitochondria-associated membranes. It accounts for ~30% of PC biosynthesis, with the CDP-choline, or Kennedy, pathway making ~70%. PC, typically the most abundant phospholipid in animals and plants, accounts for more than half of cell membrane phospholipids and approximately 30% of all cellular lipid content. The PEMT pathway is therefore crucial for maintaining membrane integrity.
Pathway
Acetylcholine Synthesis, organism-specific biosystem; Glycerophospholipid biosynthesis, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Phospholipid metabolism, organism-specific biosystem.

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References


Vance, JE; Vance, DE; et al. Phospholipid biosynthesis in mammalian cells. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 82:113-128(2004).
Pey, J; Tobalina, L; et al. A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype. BMC SYSTEMS BIOLOGY 7:-(2013).

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