Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events; Activation of PKB; Adaptive Immune System; Aldosterone-regulated sodium reabsorption; B Cell Receptor Signaling Pathway; BCR signaling pathway; BDNF signaling pathway; CD28 co-stimulation;
Citations
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