Anti-PDLIM2 monoclonal antibody (DCABH-938)

Mouse anti-Human PDLIM2 monoclonal antibody for WB, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
0C7
Species Reactivity
Dog, Human, Monkey
Immunogen
Full length recombinant Human PDLIM2 (NP_067643) produced in HEK293T cells.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/2000; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PDLIM2; PDZ and LIM domain 2 (mystique); PDZ and LIM domain protein 2; SLIM; MYSTIQUE; FLJ34715
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PDLIM2 (PDZ And LIM Domain 2) is a Protein Coding gene. Among its related pathways are Immune response_IL-12 signaling pathway. GO annotations related to this gene include alpha-actinin binding and filamin binding. An important paralog of this gene is PDLIM4. This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene. 0The function about PDLIM2 antigen include filamin-A binding; metal ion binding; muscle alpha-actinin binding; myosin heavy chain binding; nonmuscle alpha-actinin binding; zinc ion binding.

Citations


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References


Loughran, G; Healy, NC; et al. Mystique is a new insulin-like growth factor-l-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth. MOLECULAR BIOLOGY OF THE CELL 16:1811-1822(2005).
Bowe, RA; Cox, OT; et al. PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome. MOLECULAR BIOLOGY OF THE CELL 25:184-195(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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