Anti-PDE7B monoclonal antibody, clone FQS22502

Antibody Isotype

IgG

Clone

FQS22502

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human PDE7B aa 1-100 (Cysteine residue). The exact sequence is proprietary.Database link: Q9NP56

Conjugate

Application Notes

ICC/IF: 1/100 - 1/250; Flow Cyt: 1/500 - 1/1000; IHC-P: 1/250 - 1/500; WB: 1/1000 - 1/5000.

Alternative Names

PDE7B; phosphodiesterase 7B; cAMP-specific 3,5-cyclic phosphodiesterase 7B; rolipram-insensitive phosphodiesterase type 7; high-affinity cAMP-specific 3,5-cyclic phosphodiesterase; bA472E5.1; MGC88256;

Entrez Gene ID

UniProt ID

Antigen Description

PDE7B is a cAMP specific phosphodiesterase. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE7B has three splice variants (PDE7B1 = 446 amino acid; PDE7B2 =359 amino acids and PDE7B3 = 459 amino acids. Both PDE7B2 ad PDE7B3 posses unique N-terminal sequences. PDE7B is expressed in various tissues including skeletal muscle, heart, lung and testis. PDE7B may be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Pathway

G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem;