Specifications
Species Reactivity
Mouse; Rat; Hamster; Human; Monkey
Immunogen
Recombinant fragment corresponding to Human PCNA. Expressed in E.coli.Database link: P12004
Applications
Application Notes
IHC/IF: 1/100; WB: 1/1000.
Target
Alternative Names
PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein; MGC8367;
Product Background
Antigen Description
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerases processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3-5 exonuclease and 3-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2.
Pathway
BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Citations
Publication ()
Have you cited DCABH-7896 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
