Anti-PAX6 (aa 267-280) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide: C-REEKLRNQRRQASN, corresponding to internal sequence amino acids 267-280 of Human PAX6

Conjugate

Application Notes

WB: 0.3 - 1 μg/ml.

Alternative Names

PAX6; paired box 6; AN2, paired box gene 6 (aniridia, keratitis); paired box protein Pax-6; AN; aniridia; keratitis; D11S812E; WAGR; oculorhombin; aniridia type II protein; paired box homeotic gene-6; AN2; MGDA; MGC17209;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Pathway

CDC42 signaling events; Developmental Biology; Incretin Synthesis, Secretion, and Inactivation; Integration of energy metabolism; Maturity onset diabetes of the young; Metabolism;