Anti-PAX6 (aa 267-285) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Sheep; Cow; Dog; Human; Rhesus monkey

Immunogen

Synthetic peptide corresponding to Mouse PAX6 aa 267-285.Sequence: REEKLRNQRRQASNTPSHI

Conjugate

Application Notes

Flow Cyt: 1/100; IP: 5 μg/ml; ICC/IF: 1/50; WB: 1/1000.

Alternative Names

PAX6; paired box gene 6; paired box protein Pax-6; small eye; oculorhombin; Dickies small eye; Dey; Sey; AEY11; Pax-6; Gsfaey11; 1500038E17Rik;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Pathway

Incretin Synthesis, Secretion, and Inactivation; Integration of energy metabolism; Maturity onset diabetes of the young; Metabolism; Regulation of Insulin Secretion; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1);