Anti-PAX6 monoclonal antibody, clone 204DU26.3.3

Antibody Isotype

IgM

Clone

204DU26.3.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-16000; IF: 1:10-50

Alternative Names

PAX6; AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes paired box gene 6, one of many humanhomologs of the Drosophila melanogaster gene prd. In addition tothe hallmark feature of this gene family, a conserved paired boxdomain, the encoded protein also contains a homeo box domain. Bothdomains are known to bind DNA, and function as regulators of genetranscription. This gene is expressed in the developing nervoussystem, and in developing eyes. Mutations in this gene are known tocause ocular disorders such as aniridia and Peter's anomaly.Alternatively spliced transcript variants encoding either the sameor different isoform have been found for this gene. [provided byRefSeq].

Pathway

CDC42 signaling events; Cardiac Progenitor Differentiation; Developmental Biology; Incretin Synthesis, Secretion, and Inactivation; Maturity onset diabetes of the young; Metabolism of proteins; Peptide hormone metabolism; Regulation of beta-cell development;