Anti-PAX3 (aa 84-165) polyclonal antibody

Species Reactivity

Human

Immunogen

PAX3 (NP_000429, 84 a.a. ~ 165 a.a) partial recombinant protein with GST tag. The sequence is SKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVC DRNTVPSVSSISRILRSKFGKG

Conjugate

Alternative Names

PAX3; paired box 3; WS1; WS3; CDHS; HUP2; paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Pathway

Neural Crest Differentiation; Transcriptional misregulation in cancer;