Rabbit Anti-Human PATZ1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human POZ (BTB) and AT hook containing zinc finger 1

Conjugate

Application Notes

WB: 1:200-1:1000

General Notes

This product (Catalog No. DPABH-04086) is a rabbit-derived polyclonal antibody raised against human PATZ1. This antibody exhibits cross-reactivity with PATZ1 from mouse. It has been affinity purified by Protein A. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
DPABH-04086 is suitable for use in Western blot (WB) (1:200–1:1,000) application.
DPABH-04086 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23

Entrez Gene ID

UniProt ID