Anti-PALB2 (aa 553-582) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human PALB2 aa 553-582 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q86YC2

Conjugate

Application Notes

Flow Cyt: 1/10 - 1/50; WB: 1/100 - 1/500.

Alternative Names

PALB2; partner and localizer of BRCA2; FANCN; Fanconi anemia; complementation group N; FLJ21816; PNCA3; DKFZp667I166; DKFZp686E1054;

Entrez Gene ID

UniProt ID

Antigen Description

Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.

Pathway

DNA Repair; Fanconi Anemia pathway; Fanconi anemia pathway;