Anti-PAK4 (aa 68-157) polyclonal antibody

Species Reactivity

Human

Immunogen

PAK4 (AAH02921, 68 a.a. ~ 157 a.a) partial recombinant protein with GST tag. The sequence is KTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEKPPGPRSP QREPQRVSHEQFRAALQLVVDPGDPRSYLD

Conjugate

Alternative Names

PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs;

Entrez Gene ID

UniProt ID

Antigen Description

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Pathway

Activation of Rac; Axon guidance; Developmental Biology; ErbB signaling pathway