Anti-PAK3 monoclonal Antibody, clone FQ808Z

Antibody Isotype

IgG

Clone

FQ808Z

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide within Human PAK3 aa 1-100 (N terminal). The exact sequence is proprietary.

Conjugate

Application Notes

Recommended concentration:
WB: 1/10000 - 1/50000
IHC-P: 1/100 - 1/250

Alternative Names

PAK3; p21 protein (Cdc42/Rac)-activated kinase 3; mental retardation, X linked 47 , MRX30, MRX47, p21 (CDKN1A) activated kinase 3; serine/threonine-protein kinase PAK 3; bPAK; hPAK3; PAK-3; beta-PAK; oligophrenin-3; p21-activated kinase 3; p21 (CDKN1A)-a

Entrez Gene ID

UniProt ID

Antigen Description

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK3 forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. It may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.

Pathway

Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem;