PACS1 is a coat protein that is involved in the localization of trans Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. PACS1 is known to interact with HIV-1 Nef, AP-1 and AP-3 but not with AP-2.
Pathway
Disease; Host Interactions of HIV factors; Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters;
Citations
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