Rabbit Anti-PACS1 Polyclonal Antibody (DPABH-23629)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant funsion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2).
Conjugate
Unconjugated

Applications


Application Notes
WB:    1:1000 - 1:3000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Western blot analysis of extracts of 293T cells, using PACS1 antibody at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.

Target


Alternative Names
PACS1; phosphofurin acidic cluster sorting protein 1; MRD17; PACS-1; cytosolic sorting protein PACS-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PACS1 (Phosphofurin Acidic Cluster Sorting Protein 1) is a Protein Coding gene. Diseases associated with PACS1 include mental retardation, autosomal dominant 17 and intellectual disability-craniofacial dysmorphism-cryptorchidism syndrome. Among its related pathways are Infectious disease and Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters. GO annotations related to this gene include ion channel binding. An important paralog of this gene is PACS2. This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
Antigen Description
PACS1 is a coat protein that is involved in the localization of trans Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. PACS1 is known to interact with HIV-1 Nef, AP-1 and AP-3 but not with AP-2. Mental retardation, autosomal dominant 17 (MRD17) [MIM:615009]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD17 patients have intellectual disability in combination with distinct craniofacial features and genital abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry. Phosphofurin acidic cluster sorting protein 1 also known as PACS-1 is a protein that in humans is encoded by the PACS1 gene. The PACS-1 protein has a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the proteases phosphorylated cytosolic domain. The function about PACS1 antigen include ion channel binding; protein binding.

Citations


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References


Obara, T; Mangos, S; et al. Polycystin-2 immunolocalization and function in zebrafish. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 17:2706-2718(2006).

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