Anti-Ommata Synaptic Vesicles monoclonal antibody (DMAB9277)
Mouse anti-Ommata Synaptic Vesicles monoclonal antibody for IHC, IP, WB, IHC
Datasheet
Bring this labeled antibody directly to your bench!
Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
SV2
Species Reactivity
N/A
Immunogen
synaptic vesicles origin in ommata electric organ.
Conjugate
Unconjugated
Target
Alternative Names
synaptic vesicles; neurotransmitter vesicles
Product Background
Antigen Description
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating nerve impulses between neurons and are constantly recreated by the cell. The area in the axon that holds groups of vesicles is an axon terminal or "bouton". Up to 130 vesicles can be released per bouton over a ten-minute period of stimulation at 0. 2 Hz. In the human brain region V1 synaptic vesicles have an average diameter of 39. 5 nanometers with a standard deviation of 5. 1 nanometers.
Citations
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References
Zhang, YP; Wan, P; et al. Effect of neuronal excitotoxicity on Munc18-1 distribution in nuclei of rat hippocampal neuron and primary cultured neuron. NEUROSCIENCE BULLETIN 27:163-172(2011).
Ando, K; Kudo, Y; et al. Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage. JOURNAL OF NEUROCHEMISTRY 94:651-658(2005).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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