Anti-Omalizumab ELISA Kit (DEIABL217)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
96T
Sample
Serum, plasma
Species Reactivity
Human
Intended Use
Qualitative Antibodies to Omalizumab ELISA has been especially developed for the qualitative analysis of antibodies to omalizumab in serum and plasma samples.
Storage
The kit is shipped at ambient temperature (10-30°C) and should be stored at 2-8°C for long term storage. Keep away from heat or direct sunlight. The strips of microtiter plate are stable up to the expiry date of the kit in the broken, but tightly closed bag when stored at 2-8°C.
Precision
Intra-assay and inter-assay CVs <30%.
General Description
Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) which treats the symptoms of asthma and chronic idiopathic urticaria by limiting the allergic response. It inhibits the binding of IgE to receptors on mast cells and basophils, blocking the IgE-mediated secretion of inflammatory mediators from these cells. Mast cell activation and the release of mediators, in response to allergen exposure and IgE, results in a cascade of events. This cascade culminates in the activation of B-lymphocytes, T-lymphocytes, eosinophils, fibroblasts, smooth muscle cells, and the endothelium. This cellular interaction, as well as the release of cytokines, chemokines and growth factors and inflammatory remodelling of the airway results in chronic asthma.

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References


Zietkowski, Z; Skiepko, R; et al. RANTES in Exhaled Breath Condensate of Patients with Severe Persistent Allergic Asthma during Omalizumab Therapy. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 154:25-32(2011).
Patella, V; Florio, G; et al. IgE mediated food allergy (urticaria and angioedema) treated with omalizumab a recombinant humanised antiimmunoglobulin E antibody. ALLERGY 68:571-571(2013).

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