General Notes
This product (Catalog No. DPABH-10917) is a rabbit-derived polyclonal antibody raised against human OR1F1. It has been affinity purified by Protein A. OR1F1 is a protein-coding gene in humans that encodes olfactory receptor family 1 subfamily F member 1 (OR1F1), a seven-transmembrane G protein-coupled receptor (GPCR) expressed in the olfactory epithelium of the nasal cavity. This receptor interacts with odorant molecules to initiate a neuronal response, triggering the perception of smell through G protein-mediated signal transduction. As part of the largest multigene family in the human genome, OR1F1 belongs to class A (rhodopsin-like) GPCRs and features a single coding exon typical of many olfactory receptor genes. The OR1F1 gene is located on the short arm of chromosome 16 at position 16p13.3, spanning approximately 18 kb from base pairs 3,188,204 to 3,206,556 (GRCh38.p14 assembly). It produces multiple transcript variants, including a canonical isoform of 312 amino acids with a conserved 7tmA domain essential for ligand binding and receptor activation. Expression is primarily restricted to olfactory sensory neurons, where it contributes to the vast repertoire of odor discrimination; however, low-level expression has been noted in other tissues based on transcriptomic data. The gene has numerous orthologs across vertebrates, reflecting its evolutionary conservation in olfaction. Aliases for OR1F1 include OLFMF, OR16-36, OR16-37, OR16-88, and others, stemming from early mapping efforts near the familial Mediterranean fever locus. While no direct disease associations have been established, olfactory receptors like OR1F1 are studied for their role in sensory physiology and potential implications in anosmia or odor-related behaviors. Research continues to explore specific odorant ligands and structural dynamics of this receptor family.
DPABH-10917 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200) applications.
DPABH-10917 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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