Anti-OAS2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human OAS2 is used for rabbit immunization.

Conjugate

Alternative Names

OAS2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2 5 oligoadenylate synthetase 2 (69 71 kD); 2-5-oligoadenylate synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; (2-5)oligo(A) synthetase 2; MGC78578;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

Pathway

Cytokine Signaling in Immune system, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem;