Anti-NDFIP1 monoclonal antibody, clone O2Oufsn26-43.9

Antibody Isotype

IgG2b

Clone

O2Oufsn26-43.9

Species Reactivity

Mouse

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to mouse Ndfip1.

Conjugate

Application Notes

WB (1:500) & The optimal working dilution should be determined by the end user.

Alternative Names

NDFIP1; Nedd4 family interacting protein 1; NEDD4 family-interacting protein 1; Nedd4 WW binding protein 5; Nedd4 WW-binding protein 5; NEDD4 WW domain-binding protein 5; N4wbp5; 0610010M22Rik;

Entrez Gene ID

UniProt ID

Antigen Description

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.