Anti-N. gruberi Nucleolus-Like Particles Monoclonal antibody (DMAB9300)

Mouse Anti-N. gruberi Nucleolus-Like Particles Monoclonal antibody for IH, WB, IHC, IP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Species Reactivity
N. gruberi
Immunogen
nucleolus-like particles (NLP)
Conjugate
Unconjugated

Target


Alternative Names
NLP; nucleoi nucleolus-like particles; Nucleoli; nucleolus-like particles

Product Background


Antigen Description
Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome. 0Nucleoli, the sites of rRNA synthesis, rRNA processing, and the assembly of ribosomes, are dynamic organelles that, in most cells, disperse and reform during mitosis. The mechanisms that regulate nucleolar formation are unknown as is the relationship between nucleolar morphology and the pathway of ribosome biogenesis. In this report we describe the in vitro formation of nucleolus-like particles (NLPs) from soluble extracts of nucleoli. NLPs, which reached sizes comparable to nucleoli (1-3 microns), were found to contain 40% of the nucleolar DNA, RNA, and protein. The ultrastructure of NLPs resembled that of a number of in vivo structures including compact nucleoli, prenucleolar bodies, and pseudonucleoli. The particles were composed of two morphologically distinct regions. The core resembled the dense fibrillar component (DFC) of nucleoli while the cortex resembled the granular component (GC) of nucleoli. The cortex of NLPs contained numerous 15-20 nm osmophilic granules that resembled the preribosomes found in the GC of nucleoli. The distribution of nucleolar proteins in NLPs also resembled that in nucleoli.

Citations


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References


Kumar, A; Nair, SB; et al. An artificial immune system based approach for English grammar checking. Artificial Immune Systems, Proceedings 4628:348-357(2007).
Chen, XY; Wang, SM; et al. Creation of Lung-Targeted Dexamethasone Immunoliposome and Its Therapeutic Effect on Bleomycin-Induced Lung Injury in Rats. PLOS ONE 8:-(2013).

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