Anti-NRG2 (aa 116-215) polyclonal antibody

Species Reactivity

Human

Immunogen

NRG2 (NP_004874, 116 a.a. ~ 215 a.a) partial recombinant protein with GST tag. The sequence is SLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQ REQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLD

Conjugate

Alternative Names

NRG2; neuregulin 2; DON1; HRG2; NTAK; pro-neuregulin-2, membrane-bound isoform; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.

Pathway

Adaptive Immune System; DAP12 interactions; Disease; Downstream signal transduction