Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Pathway
Energy Metabolism; Fatty acid, triacylglycerol, and ketone body metabolism; Huntingtons disease; Metabolism; Metabolism of lipids and lipoproteins; Mitochondrial Gene Expression;
Citations
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