Anti-NR2C2 (aa 43-152) polyclonal antibody

Species Reactivity

Human

Immunogen

NR2C2 (NP_003289, 43 a.a. ~ 152 a.a) partial recombinant protein with GST tag. The sequence is KIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSD NLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVS

Conjugate

Alternative Names

NR2C2; nuclear receptor subfamily 2, group C, member 2; TR4; TAK1; nuclear receptor subfamily 2 group C member 2; orphan nuclear receptor TR4; Nuclear hormone receptor TR4; orphan nuclear receptor TAK1; testicular nuclear receptor 4;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Pathway

Androgen receptor signaling pathway; Generic Transcription Pathway; Nuclear Receptors; TNF-alpha/NF-kB Signaling Pathway